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Kokain oder Cocain (auch Benzoylecgoninmethylester) ist ein starkes Stimulans und Betäubungsmittel. Es findet weltweit Anwendung als Rauschdroge mit. Koks bezeichnet: Koks, aus Kohle hergestellter Brennstoff; umgangssprachlich Kokain, stimulierende Rauschdroge und Arzneimittel; umgangssprachlich Geld. De Kokain (oder Cocain) ass ee Stimulant an eng pyschoaktiv Drog mat héijem Dohier gëtt Methamphetamin dacks ënner dem Numm Kokain verkaaft. Koks (von englisch coke, seltener coaks) ist ein poröser, stark kohlenstoffhaltiger Brennstoff mit hoher spezifischer Oberfläche, der aus Kohle durch. Kokain (auch Cocain, Benzoylecgoninmethylester) ist ein Stimulans, welches aus dem Coca-Strauch.

Wiki Kokain

koosanker.online Erowid - Cocaine Die englischsprachige Website ist eine Online-Datenbank mit Informationen zu psychoaktiven Substanzen. Kokain oder Cocain ist ein starkes Stimulans. Als Stimulans definiert die WHO Substanzen, die die. Kokain. siehe unter Cocain. Unterstützen Sie das PharmaWiki mit einer Spende! © PharmaWiki - PharmaWiki informiert unabhängig und zuverlässig.

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When the Spanish arrived in South America , most at first ignored aboriginal claims that the leaf gave them strength and energy, and declared the practice of chewing it the work of the Devil.

When they wished to make themselves drunk and out of judgment they chewed a mixture of tobacco and coca leaves which make them go as they were out of their wittes.

In , Padre Blas Valera wrote:. Coca protects the body from many ailments, and our doctors use it in powdered form to reduce the swelling of wounds, to strengthen broken bones, to expel cold from the body or prevent it from entering, and to cure rotten wounds or sores that are full of maggots.

And if it does so much for outward ailments, will not its singular virtue have even greater effect in the entrails of those who eat it?

Although the stimulant and hunger-suppressant properties of coca had been known for many centuries, the isolation of the cocaine alkaloid was not achieved until Various European scientists had attempted to isolate cocaine, but none had been successful for two reasons: the knowledge of chemistry required was insufficient at the time, [ citation needed ] and contemporary conditions of sea-shipping from South America could degrade the cocaine in the plant samples available to European chemists.

The cocaine alkaloid was first isolated by the German chemist Friedrich Gaedcke in Gaedcke named the alkaloid "erythroxyline", and published a description in the journal Archiv der Pharmazie.

In , Friedrich Wöhler asked Dr. Carl Scherzer , a scientist aboard the Novara an Austrian frigate sent by Emperor Franz Joseph to circle the globe , to bring him a large amount of coca leaves from South America.

In , the ship finished its travels and Wöhler received a trunk full of coca. Wöhler passed on the leaves to Albert Niemann , a PhD student at the University of Göttingen in Germany, who then developed an improved purification process.

Niemann described every step he took to isolate cocaine in his dissertation titled Über eine neue organische Base in den Cocablättern On a New Organic Base in the Coca Leaves , which was published in —it earned him his PhD and is now in the British Library.

He wrote of the alkaloid's "colourless transparent prisms" and said that "Its solutions have an alkaline reaction, a bitter taste, promote the flow of saliva and leave a peculiar numbness, followed by a sense of cold when applied to the tongue.

The first synthesis and elucidation of the structure of the cocaine molecule was by Richard Willstätter in With the discovery of this new alkaloid, Western medicine was quick to exploit the possible uses of this plant.

In , Vassili von Anrep, of the University of Würzburg , devised an experiment to demonstrate the analgesic properties of the newly discovered alkaloid.

He prepared two separate jars, one containing a cocaine-salt solution, with the other containing merely salt water. He then submerged a frog's legs into the two jars, one leg in the treatment and one in the control solution, and proceeded to stimulate the legs in several different ways.

The leg that had been immersed in the cocaine solution reacted very differently from the leg that had been immersed in salt water. Karl Koller a close associate of Sigmund Freud , who would write about cocaine later experimented with cocaine for ophthalmic usage.

In an infamous experiment in , he experimented upon himself by applying a cocaine solution to his own eye and then pricking it with pins.

His findings were presented to the Heidelberg Ophthalmological Society. Also in , Jellinek demonstrated the effects of cocaine as a respiratory system anesthetic.

In , William Halsted demonstrated nerve-block anesthesia, [] and James Leonard Corning demonstrated peridural anesthesia. In , an Italian doctor , Paolo Mantegazza , returned from Peru , where he had witnessed first-hand the use of coca by the local indigenous peoples.

He proceeded to experiment on himself and upon his return to Milan he wrote a paper in which he described the effects. In this paper he declared coca and cocaine at the time they were assumed to be the same as being useful medicinally, in the treatment of "a furred tongue in the morning, flatulence , and whitening of the teeth.

A chemist named Angelo Mariani who read Mantegazza's paper became immediately intrigued with coca and its economic potential. In , Mariani started marketing a wine called Vin Mariani , which had been treated with coca leaves, to become cocawine.

The ethanol in wine acted as a solvent and extracted the cocaine from the coca leaves, altering the drink's effect.

A "pinch of coca leaves" was included in John Styth Pemberton 's original recipe for Coca-Cola , though the company began using decocainized leaves in when the Pure Food and Drug Act was passed.

In cocaine began to be used to treat morphine addiction. Cocaine was introduced into clinical use as a local anesthetic in Germany in , about the same time as Sigmund Freud published his work Über Coca , in which he wrote that cocaine causes: [].

Exhilaration and lasting euphoria, which in no way differs from the normal euphoria of the healthy person. You perceive an increase of self-control and possess more vitality and capacity for work.

In other words, you are simply normal, and it is soon hard to believe you are under the influence of any drug. Long intensive physical work is performed without any fatigue.

This result is enjoyed without any of the unpleasant after-effects that follow exhilaration brought about by alcoholic beverages.

No craving for the further use of cocaine appears after the first, or even after repeated taking of the drug.

In the U. The company promised that its cocaine products would "supply the place of food, make the coward brave, the silent eloquent and render the sufferer insensitive to pain.

By the late Victorian era , cocaine use had appeared as a vice in literature. For example, it was injected by Arthur Conan Doyle 's fictional Sherlock Holmes , generally to offset the boredom he felt when he was not working on a case.

In early 20th-century Memphis, Tennessee , cocaine was sold in neighborhood drugstores on Beale Street , costing five or ten cents for a small boxful.

Stevedores along the Mississippi River used the drug as a stimulant, and white employers encouraged its use by black laborers.

During the mids, amidst World War II, cocaine was considered for inclusion as an ingredient of a future generation of 'pep pills' for the German military, code named D-IX.

In modern popular culture, references to cocaine are common. The drug has a glamorous image associated with the wealthy, famous and powerful, and is said to make users "feel rich and beautiful".

In many countries, cocaine is a popular recreational drug. In the United States, the development of "crack" cocaine introduced the substance to a generally poorer inner-city market.

Use of the powder form has stayed relatively constant, experiencing a new height of use during the late s and early s in the U.

Cocaine use is prevalent across all socioeconomic strata, including age, demographics, economic, social, political, religious, and livelihood.

The estimated U. Cocaine's status as a club drug shows its immense popularity among the "party crowd". However, a decision by an American representative in the World Health Assembly banned the publication of the study, because it seemed to make a case for the positive uses of cocaine.

An excerpt of the report strongly conflicted with accepted paradigms, for example "that occasional cocaine use does not typically lead to severe or even minor physical or social problems.

This led to the decision to discontinue publication. A part of the study was recuperated and published in , including profiles of cocaine use in 20 countries, but are unavailable as of [update].

In October it was reported that the use of cocaine in Australia has doubled since monitoring began in A problem with illegal cocaine use, especially in the higher volumes used to combat fatigue rather than increase euphoria by long-term users, is the risk of ill effects or damage caused by the compounds used in adulteration.

The normal adulterants for profit are inactive sugars, usually mannitol, creatine or glucose, so introducing active adulterants gives the illusion of purity and to 'stretch' or make it so a dealer can sell more product than without the adulterants.

The production, distribution, and sale of cocaine products is restricted and illegal in most contexts in most countries as regulated by the Single Convention on Narcotic Drugs , and the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.

In the United States the manufacture, importation, possession, and distribution of cocaine are additionally regulated by the Controlled Substances Act.

Some countries, such as Peru and Bolivia, permit the cultivation of coca leaf for traditional consumption by the local indigenous population , but nevertheless, prohibit the production, sale, and consumption of cocaine.

The US federal government instituted a national labeling requirement for cocaine and cocaine-containing products through the Pure Food and Drug Act of While this act is often seen as the start of prohibition, the act itself was not actually a prohibition on cocaine, but instead set up a regulatory and licensing regime.

In , according to the United Nations , tonnes of cocaine were seized globally by law enforcement authorities. Because of the drug's potential for addiction and overdose, cocaine is generally treated as a " hard drug ", with severe penalties for possession and trafficking.

Demand remains high, and consequently, black market cocaine is quite expensive. Unprocessed cocaine, such as coca leaves , are occasionally purchased and sold, but this is exceedingly rare as it is much easier and more profitable to conceal and smuggle it in powdered form.

Colombia is as of the world's largest cocaine producer, with production more than tripling since This, combined with crop reductions in Bolivia and Peru, made Colombia the nation with the largest area of coca under cultivation after the mids.

Coca grown for traditional purposes by indigenous communities, a use which is still present and is permitted by Colombian laws, only makes up a small fragment of total coca production, most of which is used for the illegal drug trade.

An interview with a coca farmer published in described a mode of production by acid-base extraction that has changed little since The leaves were dried for half a day, then chopped into small pieces with a string trimmer and sprinkled with a small amount of powdered cement replacing sodium carbonate from former times.

Once powdered caustic soda was added to this, the cocaine precipitated and could be removed by filtration through a cloth. The resulting material, when dried, was termed pasta and sold by the farmer.

Repeated recrystallization from solvents, producing pasta lavada and eventually crystalline cocaine were performed at specialized laboratories after the sale.

Attempts to eradicate coca fields through the use of defoliants have devastated part of the farming economy in some coca growing regions of Colombia, and strains appear to have been developed that are more resistant or immune to their use.

Whether these strains are natural mutations or the product of human tampering is unclear. These strains have also shown to be more potent than those previously grown, increasing profits for the drug cartels responsible for the exporting of cocaine.

Although production fell temporarily, coca crops rebounded in numerous smaller fields in Colombia, rather than the larger plantations.

The cultivation of coca has become an attractive economic decision for many growers due to the combination of several factors, including the lack of other employment alternatives, the lower profitability of alternative crops in official crop substitution programs, the eradication-related damages to non-drug farms, the spread of new strains of the coca plant due to persistent worldwide demand.

The latest estimate provided by the U. As of the end of , the seizure operations of Colombian cocaine carried out in different countries have totaled Department of State's estimates.

Synthetic cocaine would be highly desirable to the illegal drug industry as it would eliminate the high visibility and low reliability of offshore sources and international smuggling, replacing them with clandestine domestic laboratories, as are common for illicit methamphetamine.

However, natural cocaine remains the lowest cost and highest quality supply of cocaine. Actual full synthesis of cocaine is rarely done. Formation of inactive stereoisomers cocaine has 4 chiral centres — 1 R , 2 R , 3 S , and 5 S , 2 of them dependent, hence a total potential of 8 possible stereoisomers plus synthetic by-products limits the yield and purity.

Organized criminal gangs operating on a large scale dominate the cocaine trade. As of [update] , cocaine shipments from South America transported through Mexico or Central America were generally moved over land or by air to staging sites in northern Mexico.

The cocaine is then broken down into smaller loads for smuggling across the U. The primary cocaine importation points in the United States have been in Arizona , southern California , southern Florida , and Texas.

Typically, land vehicles are driven across the U. Sixty-five percent of cocaine enters the United States through Mexico, and the vast majority of the rest enters through Florida.

Cocaine traffickers from Colombia and Mexico have established a labyrinth of smuggling routes throughout the Caribbean, the Bahama Island chain, and South Florida.

They often hire traffickers from Mexico or the Dominican Republic to transport the drug using a variety of smuggling techniques to U.

Another route of cocaine traffic goes through Chile, which is primarily used for cocaine produced in Bolivia since the nearest seaports lie in northern Chile.

While the price of cocaine is higher in Chile than in Peru and Bolivia, the final destination is usually Europe, especially Spain where drug dealing networks exist among South American immigrants.

Cocaine is also carried in small, concealed, kilogram quantities across the border by couriers known as " mules " or "mulas" , who cross a border either legally, for example, through a port or airport, or illegally elsewhere.

The drugs may be strapped to the waist or legs or hidden in bags, or hidden in the body. If the mule gets through without being caught, the gangs will reap most of the profits.

If he or she is caught, however, gangs will sever all links and the mule will usually stand trial for trafficking alone. Bulk cargo ships are also used to smuggle cocaine to staging sites in the western Caribbean— Gulf of Mexico area.

Commercial fishing vessels are also used for smuggling operations. In areas with a high volume of recreational traffic, smugglers use the same types of vessels, such as go-fast boats , as those used by the local populations.

Sophisticated drug subs are the latest tool drug runners are using to bring cocaine north from Colombia, it was reported on 20 March Although the vessels were once viewed as a quirky sideshow in the drug war, they are becoming faster, more seaworthy, and capable of carrying bigger loads of drugs than earlier models, according to those charged with catching them.

Cocaine is readily available in all major countries' metropolitan areas. According to the Summer Pulse Check , published by the U.

Twenty dollars might purchase 0. Quality and price can vary dramatically depending on supply and demand, and on geographic region.

Between and , the value of the market remained basically stable". In , researchers proposed the use of cocaine in conjunction with phenylephrine administered in the form of an eye drop as a diagnostic test for Parkinson's disease.

From Wikipedia, the free encyclopedia. Strong stimulant used as a recreational drug. For other uses, see Cocaine disambiguation.

US : C Risk not ruled out [4]. CNS stimulant Local anesthetic. IUPAC name. Interactive image. This article needs more medical references for verification or relies too heavily on primary sources.

Please review the contents of the article and add the appropriate references if you can. Unsourced or poorly sourced material may be challenged and removed.

See also: Crack cocaine. Main article: Cocaine intoxication. See also: Epigenetics of cocaine addiction. Main article: Freebase chemistry.

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources.

Unsourced material may be challenged and removed. Main article: Crack cocaine. Main article: Biosynthesis of cocaine.

Main article: List of countries by prevalence of cocaine use. Main article: Cocaine in the United States. Main article: Legal status of cocaine.

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Psychology Press. Walaupun paling biasa digunakan secara rekreasi untuk kesan ini, kokaina ialah anestesia topikal yang digunakan untuk pembedahan mata , tekak, dan hidung.

Kokaina boleh mengakibatkan ketagihan psikologi, dan pemilikan, penanaman, serta pengedarannya untuk kegunaan bukan perubatan atau kegunaan yang tidak dibenarkan oleh kerajaan adalah haram di hampir-hampir semua negara di dunia.

Namanya berasal daripada nama tumbuhan koka. Nama kimianya ialah [1R- ekso,ekso ] benzoiloksi metilazabisiklo[3. Sifat-sifat perangsangan daun koka dikenali oleh orang-orang kuno dari Peru dan masyarakat-masyarakat Amerika Selatan Pra-Columbus.

Di negara-negara Barat moden, kokaina telah menjadi ciri budaya saingan selama melebihi satu abad ; adanya satu senarai panjang cendekiawan, artis, dan ahli muzik yang menggunakan dadah ini; nama-nama mereka termasuk Sir Arthur Conan Doyle , Sigmund Freud , dan Presiden Amerika Syarikat Ulysses S.

Selama beberapa dekad selepas pengeluaran permulaan Coca-Cola , kesan-kesan kokaina boleh didapati dalam minuman itu. Orang-orang asli Amerika Selatan telah lama mengunyah daun koka Erythroxylum coca , sejenis tumbuhan yang mengandungi zat makanan yang penting serta berbagai-bagai jenis alkaloid , termasuk kokaina.

Daun itu dikunyah dengan hampir sejagat oleh sebilangan komuniti orang asli — mumia- mumia Peru kuno telah didapati mempunyai sisa-sisa daun koka di dalam mulut, dan tembikar dari zaman itu menggambarkan manusia dengan pipi yang bonjol dengan sesuatu yang sedang dikunyah oleh mereka.

Ketika orang-orang Sepanyol menjajah Amerika Selatan , mereka pada mula-mulanya tidak mengendahkan dakwaan orang asli bahawa daun itu memberikan mereka kekuatan dan tenaga, dan mengisytiharkan pengunyahan daun koka sebagai suatu amalan syaitan.

Cukai-cukai itu merupakan sumber sokongan utama Gereja Roman Katolik di kawasan itu buat suatu masa. Pada tahun , Nicholas Monardes memerihalkan amalan orang asli mengunyah campuran tembakau dengan daun koka untuk menghasilkan "rasa amat berpuas hati":.

Pada tahun , Padre Blas Valera menulis:. Daripada Wikipedia, ensiklopedia bebas. Untuk kegunaan lain, sila lihat Kokain nyahkekaburan. Koka melindungi badan daripada banyak penyakit, dan doktor-doktor kami menggunakannya dalam bentuk serbuk untuk mengurangkan bengkak, mengukuhkan tulang patah, mengeluarkan sejuk dari badan atau mencegah pemasukannya, dan untuk merawat luka yang reput atau kudis yang penuh dengan berenga.

Dan jika ia amat berkesan terhadap penyakit luar, bukankah kebaikannya yang luar biasa itu mempunyai kesan yang jauh lebih baik kepada isi perut mereka yang makannya?

Washington, D. ISBN Surv Ophthalmol. Barnett, R. Hawks, and R.

[1] Wikipedia-Artikel „Kokain“: [1] Digitales Wörterbuch der deutschen Sprache „​Kokain“: [1] Uni Leipzig: Wortschatz-Portal „Kokain“: [1] The. Kokain oder Cocain ist ein starkes Stimulans. Als Stimulans definiert die WHO Substanzen, die die. Sofern sich der Spieler in einem entsprechenden Bereich (Kokainfeld) befindet kann mit der Leertaste "Gather Cocaine" Kokain geerntet werden. Kokain. koosanker.online Erowid - Cocaine Die englischsprachige Website ist eine Online-Datenbank mit Informationen zu psychoaktiven Substanzen. Kokain. siehe unter Cocain. Unterstützen Sie das PharmaWiki mit einer Spende! © PharmaWiki - PharmaWiki informiert unabhängig und zuverlässig. Die Forschenden schliessen daraus, dass Levamisol neurotoxisch wirken könnte und plädieren für den Ausbau sogenannter Drug-Checking-Programme. AntidepressivaWirkungsverstärker für andere Wm 2020 Spielplan Gruppe F. Dazu können auch Medikamente verwendet werden. H- und P-Sätze. Kokainabhängigkeit - Rückfall unterliegt nicht unbedingt einer bewussten Entscheidung: Kokainabhängige haben Probleme ihren Konsum zu kontrollieren. In Südamerika wird Kokainsulfat allerdings auch häufig vermischt mit Tabak geraucht, da es im Vergleich Beste Spielothek in Kilianshof finden den anderen Kokainformen sehr viel billiger ist. Bei Menschen, wo derartige direkte Experimente nicht möglich sind, kann Claw Machine Kaufen in Längsschnittstudien untersucht werden, ob die Wiki Kokain des Gebrauchs einer Substanz mit dem früheren Gebrauch Spielsucht Beratung Cham anderen Substanzen in Beziehung steht. AntidepressivaWirkungsverstärker für andere Drogen. Das Paypal# Login eine Abwasserstudie der Universität Lausanne. Der Vorgang der Verkokung von Kohle zu Koks findet in speziellen Industrieanlagen statt, die als Kokereien bezeichnet werden. In Rotterdam fand sich ein erheblicher Anteil von Konsumenten aus der Arbeiter- und Arbeitslosenschicht, während z. Nicotin TabakCytisin Goldregen. Kokainstreckmittel steht im Verdacht, Hirnschäden zu verursachen: Wer Spiele The Codfather / Scratch - Video Slots Online Kokain konsumiert, das mit dem Tierentwurmungsmittel Levamisol gestreckt wurde, zeigt schlechtere kognitive Leistungen und verfügt über eine dünnere Hirnrinde. Kokain kann zur Überhitzung führen und belastet den Kreislauf mit steigender Dosierung. In Tierversuchen kann relativ einfach festgestellt werden, ob der Konsum einer Substanz die spätere Attraktivität einer anderen Substanz für Tiere erhöht. Beim gemeinsamen Gebrauch von Schnupfröhrchen kann es bei der nasalen Applikation von Kokain zur Übertragung von Krankheitserregern kommen. Daher besteht die Gefahr, SГјd Mahjong ein unbekanntes Streckmittel enthalten ist, welches unter Umständen gesundheitsschädlich oder sogar Die Bedeutung Der Zahl 7 sein kann. Besonders problematisch ist Lidocain- oder Tetracainverschnitt, wenn Kokain weder geschnupft Spielsucht BeziehungsunfГ¤hig geraucht, sondern intravenös injiziert wird. When inhaled or injected, it causes a numbing Www.Paypal:De. Bei chronischem Konsum durch die Nase kann es zur Schädigung der Nasenscheidewand kommen und sogar zu deren Durchlöcherung. Retrieved 21 April Wiki Kokain

Cocaine's binding properties are such that it attaches so this hydrogen bond will not form and is blocked from formation due to the tightly locked orientation of the cocaine molecule.

Research studies have suggested that the affinity for the transporter is not what is involved in habituation of the substance so much as the conformation and binding properties to where and how on the transporter the molecule binds.

Sigma receptors are affected by cocaine, as cocaine functions as a sigma ligand agonist. Cocaine also blocks sodium channels , thereby interfering with the propagation of action potentials ; [72] [45] thus, like lignocaine and novocaine , it acts as a local anesthetic.

It also functions on the binding sites to the dopamine and serotonin sodium dependent transport area as targets as separate mechanisms from its reuptake of those transporters; unique to its local anesthetic value which makes it in a class of functionality different from both its own derived phenyltropanes analogues which have that removed.

In addition to this cocaine has some target binding to the site of the Kappa-opioid receptor as well. The locomotor enhancing properties of cocaine may be attributable to its enhancement of dopaminergic transmission from the substantia nigra.

Cocaine can often cause reduced food intake, many chronic users lose their appetite and can experience severe malnutrition and significant weight loss.

Cocaine effects, further, are shown to be potentiated for the user when used in conjunction with new surroundings and stimuli, and otherwise novel environs.

Cocaine has a short half life of 0. Depending on liver and kidney function, cocaine metabolites are detectable in urine. Detection of cocaine metabolites in hair is possible in regular users until the sections of hair grown during use are cut or fall out.

Cocaine in its purest form is a white, pearly product. Cocaine appearing in powder form is a salt , typically cocaine hydrochloride. Street cocaine is often adulterated or "cut" with talc , lactose , sucrose , glucose , mannitol , inositol , caffeine , procaine , phencyclidine , phenytoin , lignocaine , strychnine , amphetamine , or heroin.

The color of "crack" cocaine depends upon several factors including the origin of the cocaine used, the method of preparation — with ammonia or baking soda — and the presence of impurities.

It will generally range from white to a yellowish cream to a light brown. Its texture will also depend on the adulterants, origin and processing of the powdered cocaine, and the method of converting the base.

It ranges from a crumbly texture, sometimes extremely oily, to a hard, almost crystalline nature. Cocaine — a tropane alkaloid — is a weakly alkaline compound, and can therefore combine with acidic compounds to form salts.

Different salts dissolve to a greater or lesser extent in various solvents — the hydrochloride salt is polar in character and is quite soluble in water.

As the name implies, "freebase" is the base form of cocaine, as opposed to the salt form. It is practically insoluble in water whereas hydrochloride salt is water-soluble.

Smoking freebase cocaine has the additional effect of releasing methylecgonidine into the user's system due to the pyrolysis of the substance a side effect which insufflating or injecting powder cocaine does not create.

Some research suggests that smoking freebase cocaine can be even more cardiotoxic than other routes of administration [81] because of methylecgonidine's effects on lung tissue [82] and liver tissue.

Pure cocaine is prepared by neutralizing its compounding salt with an alkaline solution, which will precipitate to non-polar basic cocaine.

It is further refined through aqueous-solvent liquid—liquid extraction. Smoking or vaporizing cocaine and inhaling it into the lungs produces an almost immediate "high" that can be very powerful and addicting quite rapidly — this initial crescendo of stimulation is known as a "rush".

While the stimulating effects may last for hours, the euphoric sensation is very brief, prompting the user to smoke more immediately. This effectively destroys some of the cocaine and yields a sharp, acrid, and foul-tasting smoke.

The origin of the name "crack" comes from the "crackling" sound and hence the onomatopoeic moniker "crack" that is produced when the cocaine and its impurities i.

Coca herbal infusion also referred to as coca tea is used in coca-leaf producing countries much as any herbal medicinal infusion would elsewhere in the world.

The free and legal commercialization of dried coca leaves under the form of filtration bags to be used as "coca tea" has been actively promoted by the governments of Peru and Bolivia for many years as a drink having medicinal powers.

In Peru, the National Coca Company , a state-run corporation, sells cocaine-infused teas and other medicinal products and also exports leaves to the U.

Visitors to the city of Cuzco in Peru, and La Paz in Bolivia are greeted with the offering of coca leaf infusions prepared in teapots with whole coca leaves purportedly to help the newly arrived traveler overcome the malaise of high altitude sickness.

The effects of drinking coca tea are a mild stimulation and mood lift. In order to prevent the demonization of this product, its promoters publicize the unproven concept that much of the effect of the ingestion of coca leaf infusion would come from the secondary alkaloids, as being not only quantitatively different from pure cocaine but also qualitatively different.

It has been promoted as an adjuvant for the treatment of cocaine dependence. In one controversial study, coca leaf infusion was used—in addition to counseling—to treat 23 addicted coca-paste smokers in Lima , Peru.

Relapses fell from an average of four times per month before treatment with coca tea to one during the treatment.

These results suggest that the administration of coca leaf infusion plus counseling would be an effective method for preventing relapse during treatment for cocaine addiction.

Importantly, these results also suggest strongly that the primary pharmacologically active metabolite in coca leaf infusions is actually cocaine and not the secondary alkaloids.

The first synthesis and elucidation of the cocaine molecule was by Richard Willstätter in Since then, Robert Robinson and Edward Leete have made significant contributions to the mechanism of the synthesis.

The second addition occurs through a Claisen condensation. This produces a racemic mixture of the 2-substituted pyrrolidine, with the retention of the thioester from the Claisen condensation.

In formation of tropinone from racemic ethyl [2,C 2 ] 4 Nmethylpyrrolidinyl oxobutanoate there is no preference for either stereoisomer. The stereoselectivity of this reaction was further investigated through study of prochiral methylene hydrogen discrimination.

The benzoyl moiety required for the formation of the cocaine diester is synthesized from phenylalanine via cinnamic acid. The biosynthesis begins with L- Glutamine , which is derived to L- ornithine in plants.

The major contribution of L-ornithine and L- arginine as a precursor to the tropane ring was confirmed by Edward Leete. In animals, however, the urea cycle derives putrescine from ornithine.

L-ornithine is converted to L-arginine, [96] which is then decarboxylated via PLP to form agmatine. Hydrolysis of the imine derives N -carbamoylputrescine followed with hydrolysis of the urea to form putrescine.

The separate pathways of converting ornithine to putrescine in plants and animals have converged.

A SAM-dependent N -methylation of putrescine gives the N -methylputrescine product, which then undergoes oxidative deamination by the action of diamine oxidase to yield the aminoaldehyde.

The biosynthesis of the tropane alkaloid , however, is still uncertain. Hemscheidt proposes that Robinson's acetonedicarboxylate emerges as a potential intermediate for this reaction.

Decarboxylation leads to tropane alkaloid formation. The reduction of tropinone is mediated by NADPH -dependent reductase enzymes, which have been characterized in multiple plant species.

Cocaine and its major metabolites may be quantified in blood, plasma, or urine to monitor for abuse, confirm a diagnosis of poisoning, or assist in the forensic investigation of a traffic or other criminal violation or a sudden death.

Most commercial cocaine immunoassay screening tests cross-react appreciably with the major cocaine metabolites, but chromatographic techniques can easily distinguish and separately measure each of these substances.

When interpreting the results of a test, it is important to consider the cocaine usage history of the individual, since a chronic user can develop tolerance to doses that would incapacitate a cocaine-naive individual, and the chronic user often has high baseline values of the metabolites in his system.

Cautious interpretation of testing results may allow a distinction between passive or active usage, and between smoking versus other routes of administration.

Similar claims have been made in web forums on that topic. Cocaine may be detected by law enforcement using the Scott reagent. The test can easily generate false positives for common substances and must be confirmed with a laboratory test.

The shade of brown shown by the chloroform is proportional to the cocaine content. This test is not cross sensitive to heroin, methamphetamine, benzocaine, procaine and a number of other drugs but other chemicals could cause false positives.

According to a United Nations report, England and Wales are the countries with the highest rate of cocaine usage 2. Cocaine is the second most popular illegal recreational drug in Europe behind cannabis.

Since the mids, overall cocaine usage in Europe has been on the rise, but usage rates and attitudes tend to vary between countries.

Approximately 17 million Europeans 5. About 1. The ratio of male to female users is approximately 3. In London had the highest amount of cocaine in its sewage out of 50 European cities.

Cocaine is the second most popular illegal recreational drug in the United States behind cannabis [] and the U. It is also popular amongst college students, as a party drug.

A study throughout the entire United States has reported that around 48 percent of people who graduated from high school in have used cocaine recreationally during some point in their lifetime, compared to approximately 20 percent of students who graduated between the years of and In the s and s, the drug became particularly popular in the disco culture as cocaine usage was very common and popular in many discos such as Studio For over a thousand years South American indigenous peoples have chewed the leaves of Erythroxylon coca , a plant that contains vital nutrients as well as numerous alkaloids , including cocaine.

The coca leaf was, and still is, chewed almost universally by some indigenous communities. The remains of coca leaves have been found with ancient Peruvian mummies, and pottery from the time period depicts humans with bulged cheeks, indicating the presence of something on which they are chewing.

When the Spanish arrived in South America , most at first ignored aboriginal claims that the leaf gave them strength and energy, and declared the practice of chewing it the work of the Devil.

When they wished to make themselves drunk and out of judgment they chewed a mixture of tobacco and coca leaves which make them go as they were out of their wittes.

In , Padre Blas Valera wrote:. Coca protects the body from many ailments, and our doctors use it in powdered form to reduce the swelling of wounds, to strengthen broken bones, to expel cold from the body or prevent it from entering, and to cure rotten wounds or sores that are full of maggots.

And if it does so much for outward ailments, will not its singular virtue have even greater effect in the entrails of those who eat it? Although the stimulant and hunger-suppressant properties of coca had been known for many centuries, the isolation of the cocaine alkaloid was not achieved until Various European scientists had attempted to isolate cocaine, but none had been successful for two reasons: the knowledge of chemistry required was insufficient at the time, [ citation needed ] and contemporary conditions of sea-shipping from South America could degrade the cocaine in the plant samples available to European chemists.

The cocaine alkaloid was first isolated by the German chemist Friedrich Gaedcke in Gaedcke named the alkaloid "erythroxyline", and published a description in the journal Archiv der Pharmazie.

In , Friedrich Wöhler asked Dr. Carl Scherzer , a scientist aboard the Novara an Austrian frigate sent by Emperor Franz Joseph to circle the globe , to bring him a large amount of coca leaves from South America.

In , the ship finished its travels and Wöhler received a trunk full of coca. Wöhler passed on the leaves to Albert Niemann , a PhD student at the University of Göttingen in Germany, who then developed an improved purification process.

Niemann described every step he took to isolate cocaine in his dissertation titled Über eine neue organische Base in den Cocablättern On a New Organic Base in the Coca Leaves , which was published in —it earned him his PhD and is now in the British Library.

He wrote of the alkaloid's "colourless transparent prisms" and said that "Its solutions have an alkaline reaction, a bitter taste, promote the flow of saliva and leave a peculiar numbness, followed by a sense of cold when applied to the tongue.

The first synthesis and elucidation of the structure of the cocaine molecule was by Richard Willstätter in With the discovery of this new alkaloid, Western medicine was quick to exploit the possible uses of this plant.

In , Vassili von Anrep, of the University of Würzburg , devised an experiment to demonstrate the analgesic properties of the newly discovered alkaloid.

He prepared two separate jars, one containing a cocaine-salt solution, with the other containing merely salt water.

He then submerged a frog's legs into the two jars, one leg in the treatment and one in the control solution, and proceeded to stimulate the legs in several different ways.

The leg that had been immersed in the cocaine solution reacted very differently from the leg that had been immersed in salt water.

Karl Koller a close associate of Sigmund Freud , who would write about cocaine later experimented with cocaine for ophthalmic usage. In an infamous experiment in , he experimented upon himself by applying a cocaine solution to his own eye and then pricking it with pins.

His findings were presented to the Heidelberg Ophthalmological Society. Also in , Jellinek demonstrated the effects of cocaine as a respiratory system anesthetic.

In , William Halsted demonstrated nerve-block anesthesia, [] and James Leonard Corning demonstrated peridural anesthesia. In , an Italian doctor , Paolo Mantegazza , returned from Peru , where he had witnessed first-hand the use of coca by the local indigenous peoples.

He proceeded to experiment on himself and upon his return to Milan he wrote a paper in which he described the effects. In this paper he declared coca and cocaine at the time they were assumed to be the same as being useful medicinally, in the treatment of "a furred tongue in the morning, flatulence , and whitening of the teeth.

A chemist named Angelo Mariani who read Mantegazza's paper became immediately intrigued with coca and its economic potential. In , Mariani started marketing a wine called Vin Mariani , which had been treated with coca leaves, to become cocawine.

The ethanol in wine acted as a solvent and extracted the cocaine from the coca leaves, altering the drink's effect. A "pinch of coca leaves" was included in John Styth Pemberton 's original recipe for Coca-Cola , though the company began using decocainized leaves in when the Pure Food and Drug Act was passed.

In cocaine began to be used to treat morphine addiction. Cocaine was introduced into clinical use as a local anesthetic in Germany in , about the same time as Sigmund Freud published his work Über Coca , in which he wrote that cocaine causes: [].

Exhilaration and lasting euphoria, which in no way differs from the normal euphoria of the healthy person. You perceive an increase of self-control and possess more vitality and capacity for work.

In other words, you are simply normal, and it is soon hard to believe you are under the influence of any drug. Long intensive physical work is performed without any fatigue.

This result is enjoyed without any of the unpleasant after-effects that follow exhilaration brought about by alcoholic beverages.

No craving for the further use of cocaine appears after the first, or even after repeated taking of the drug. In the U. The company promised that its cocaine products would "supply the place of food, make the coward brave, the silent eloquent and render the sufferer insensitive to pain.

By the late Victorian era , cocaine use had appeared as a vice in literature. For example, it was injected by Arthur Conan Doyle 's fictional Sherlock Holmes , generally to offset the boredom he felt when he was not working on a case.

In early 20th-century Memphis, Tennessee , cocaine was sold in neighborhood drugstores on Beale Street , costing five or ten cents for a small boxful.

Stevedores along the Mississippi River used the drug as a stimulant, and white employers encouraged its use by black laborers. During the mids, amidst World War II, cocaine was considered for inclusion as an ingredient of a future generation of 'pep pills' for the German military, code named D-IX.

In modern popular culture, references to cocaine are common. The drug has a glamorous image associated with the wealthy, famous and powerful, and is said to make users "feel rich and beautiful".

In many countries, cocaine is a popular recreational drug. In the United States, the development of "crack" cocaine introduced the substance to a generally poorer inner-city market.

Use of the powder form has stayed relatively constant, experiencing a new height of use during the late s and early s in the U.

Cocaine use is prevalent across all socioeconomic strata, including age, demographics, economic, social, political, religious, and livelihood.

The estimated U. Cocaine's status as a club drug shows its immense popularity among the "party crowd". However, a decision by an American representative in the World Health Assembly banned the publication of the study, because it seemed to make a case for the positive uses of cocaine.

An excerpt of the report strongly conflicted with accepted paradigms, for example "that occasional cocaine use does not typically lead to severe or even minor physical or social problems.

This led to the decision to discontinue publication. A part of the study was recuperated and published in , including profiles of cocaine use in 20 countries, but are unavailable as of [update].

In October it was reported that the use of cocaine in Australia has doubled since monitoring began in A problem with illegal cocaine use, especially in the higher volumes used to combat fatigue rather than increase euphoria by long-term users, is the risk of ill effects or damage caused by the compounds used in adulteration.

The normal adulterants for profit are inactive sugars, usually mannitol, creatine or glucose, so introducing active adulterants gives the illusion of purity and to 'stretch' or make it so a dealer can sell more product than without the adulterants.

The production, distribution, and sale of cocaine products is restricted and illegal in most contexts in most countries as regulated by the Single Convention on Narcotic Drugs , and the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.

In the United States the manufacture, importation, possession, and distribution of cocaine are additionally regulated by the Controlled Substances Act.

Some countries, such as Peru and Bolivia, permit the cultivation of coca leaf for traditional consumption by the local indigenous population , but nevertheless, prohibit the production, sale, and consumption of cocaine.

The US federal government instituted a national labeling requirement for cocaine and cocaine-containing products through the Pure Food and Drug Act of While this act is often seen as the start of prohibition, the act itself was not actually a prohibition on cocaine, but instead set up a regulatory and licensing regime.

In , according to the United Nations , tonnes of cocaine were seized globally by law enforcement authorities. Because of the drug's potential for addiction and overdose, cocaine is generally treated as a " hard drug ", with severe penalties for possession and trafficking.

Demand remains high, and consequently, black market cocaine is quite expensive. Unprocessed cocaine, such as coca leaves , are occasionally purchased and sold, but this is exceedingly rare as it is much easier and more profitable to conceal and smuggle it in powdered form.

Colombia is as of the world's largest cocaine producer, with production more than tripling since This, combined with crop reductions in Bolivia and Peru, made Colombia the nation with the largest area of coca under cultivation after the mids.

Coca grown for traditional purposes by indigenous communities, a use which is still present and is permitted by Colombian laws, only makes up a small fragment of total coca production, most of which is used for the illegal drug trade.

An interview with a coca farmer published in described a mode of production by acid-base extraction that has changed little since The leaves were dried for half a day, then chopped into small pieces with a string trimmer and sprinkled with a small amount of powdered cement replacing sodium carbonate from former times.

Once powdered caustic soda was added to this, the cocaine precipitated and could be removed by filtration through a cloth. The resulting material, when dried, was termed pasta and sold by the farmer.

Repeated recrystallization from solvents, producing pasta lavada and eventually crystalline cocaine were performed at specialized laboratories after the sale.

Attempts to eradicate coca fields through the use of defoliants have devastated part of the farming economy in some coca growing regions of Colombia, and strains appear to have been developed that are more resistant or immune to their use.

Whether these strains are natural mutations or the product of human tampering is unclear. These strains have also shown to be more potent than those previously grown, increasing profits for the drug cartels responsible for the exporting of cocaine.

Although production fell temporarily, coca crops rebounded in numerous smaller fields in Colombia, rather than the larger plantations.

The cultivation of coca has become an attractive economic decision for many growers due to the combination of several factors, including the lack of other employment alternatives, the lower profitability of alternative crops in official crop substitution programs, the eradication-related damages to non-drug farms, the spread of new strains of the coca plant due to persistent worldwide demand.

The latest estimate provided by the U. As of the end of , the seizure operations of Colombian cocaine carried out in different countries have totaled Department of State's estimates.

Synthetic cocaine would be highly desirable to the illegal drug industry as it would eliminate the high visibility and low reliability of offshore sources and international smuggling, replacing them with clandestine domestic laboratories, as are common for illicit methamphetamine.

However, natural cocaine remains the lowest cost and highest quality supply of cocaine. Actual full synthesis of cocaine is rarely done. Formation of inactive stereoisomers cocaine has 4 chiral centres — 1 R , 2 R , 3 S , and 5 S , 2 of them dependent, hence a total potential of 8 possible stereoisomers plus synthetic by-products limits the yield and purity.

Organized criminal gangs operating on a large scale dominate the cocaine trade. As of [update] , cocaine shipments from South America transported through Mexico or Central America were generally moved over land or by air to staging sites in northern Mexico.

The cocaine is then broken down into smaller loads for smuggling across the U. The primary cocaine importation points in the United States have been in Arizona , southern California , southern Florida , and Texas.

Typically, land vehicles are driven across the U. Sixty-five percent of cocaine enters the United States through Mexico, and the vast majority of the rest enters through Florida.

Cocaine traffickers from Colombia and Mexico have established a labyrinth of smuggling routes throughout the Caribbean, the Bahama Island chain, and South Florida.

They often hire traffickers from Mexico or the Dominican Republic to transport the drug using a variety of smuggling techniques to U.

Another route of cocaine traffic goes through Chile, which is primarily used for cocaine produced in Bolivia since the nearest seaports lie in northern Chile.

While the price of cocaine is higher in Chile than in Peru and Bolivia, the final destination is usually Europe, especially Spain where drug dealing networks exist among South American immigrants.

Cocaine is also carried in small, concealed, kilogram quantities across the border by couriers known as " mules " or "mulas" , who cross a border either legally, for example, through a port or airport, or illegally elsewhere.

The drugs may be strapped to the waist or legs or hidden in bags, or hidden in the body. If the mule gets through without being caught, the gangs will reap most of the profits.

Daripada Wikipedia, ensiklopedia bebas. Untuk kegunaan lain, sila lihat Kokain nyahkekaburan. Koka melindungi badan daripada banyak penyakit, dan doktor-doktor kami menggunakannya dalam bentuk serbuk untuk mengurangkan bengkak, mengukuhkan tulang patah, mengeluarkan sejuk dari badan atau mencegah pemasukannya, dan untuk merawat luka yang reput atau kudis yang penuh dengan berenga.

Dan jika ia amat berkesan terhadap penyakit luar, bukankah kebaikannya yang luar biasa itu mempunyai kesan yang jauh lebih baik kepada isi perut mereka yang makannya?

Washington, D. ISBN Surv Ophthalmol. Barnett, R. Hawks, and R. Resnick The Journal of Ethnopharmacology.

Weil A perspective on a new debut for an old girl". Clinical Toxicology. Joyfull Newes out of the Newe Founde Worlde. Diese unterschiedlichen Kokainverabreichungsweisen unterscheiden sich in der Zeit bis zum Wirkungseintritt, der Dauer des Rauschgefühls, der mittleren akuten Dosis, der Wirkstoffhöchstwerte im Plasma, dem Wirkstoffgehalt im konsumierten Material und der Bioverfügbarkeit.

Cocapaste, die freie Base des Kokains Freebase und Crack werden geraucht. Gerauchtes Kokain wirkt innerhalb von 8—10 Sekunden für 5—10 Minuten und bewirkt eine deutlich höhere Wirkstoffkonzentration als andere Konsumformen.

Der orale oder intranasale Konsum wirkt deutlich schwächer, dafür aber 30—45 Minuten lang. Der Wirkungseintritt erfolgt beim oralen Konsum nach 10—30 Minuten, intranasal nach 2—3 Minuten.

Dies kann Herzrhythmusstörungen bis hin zum Herzanfall zur Folge haben. Durch die Störung der Gefühle für Hunger, Durst, Schlaf und Wachen kann es zu starken Mangelerscheinungen in diesem Bereich kommen; auch das Furchtempfinden kann gestört werden.

Massiver Schlafentzug aufgrund von Kokainkonsum kann zu paranoiden Halluzinationen , Verfolgungsängsten, zeitlicher und örtlicher Desorientierung , gesteigerter Nervosität und Aggressivität führen.

Bei chronischem Konsum durch die Nase kann es zur Schädigung der Nasenscheidewand kommen und sogar zu deren Durchlöcherung.

Bei intensiven Konsumformen kann dies zu einem starken Drang nach einem sofortigen weiteren Konsum führen. Die eigentliche Gefahr beim Rauchkonsum liegt in der Überdosierung.

Beim Konsum von Freebase oder Crack ist die lebensbedrohliche Dosis variabel und unberechenbar. Die Gefahr der Überdosierung ist wegen der schnellen Aufnahme des hochkonzentrierten und in der Regel reinen Stoffes besonders hoch.

Von einer Vergiftung kann dann gesprochen werden, wenn der Drogenkonsument keine positive Wirkung mehr spürt, erste sichtbare Hinweise sind erweiterte Pupillen , leichte Krämpfe , Koordinationsstörungen , massiv erhöhte Körpertemperatur und Händezittern.

Nach der Geburt können Verhaltensauffälligkeiten bei Kindern auftreten, der Kopfumfang kann geringer sein als durchschnittlich zu erwarten wäre.

Es kann zu einer Kokainpsychose kommen, die durch paranoid wahnhafte Wahrnehmungsstörungen gekennzeichnet ist. Dermatozoenwahn ist ein charakteristisches Symptom, hierbei glaubt der Betroffene, Insekten krabbelten unter seiner Haut.

Diese Zustände können chronisch bleiben. Nach dem Kokainrausch kann eine Depression auftreten. Dieser Mechanismus ist gefährlich, da er schnell zu einer Abhängigkeit führen kann.

Das extreme Hochgefühl sowie das schnelle Abklingen der Wirkung steigert das Abhängigkeitspotential der Droge erheblich.

Unter Umständen kann es demnach bereits nach dem ersten Kokainkonsum zu einer psychischen Abhängigkeit kommen.

Eine physische Abhängigkeit tritt nicht ein. Im Extremfall kann diese Konsumdynamik sog. Eine Besonderheit bei langfristigem Kokainmissbrauch ist das Auftreten des sogenannten Dermatozoenwahns , der Überzeugung, dass sich Insekten unter der eigenen Haut bewegen.

Kokain- Substanzverlangen wird meist durch Schlüsselreize ausgelöst Gerüche, Musik, Bilder , durch bestimmte Situationen Stress , Stimmungen, Orte und fast immer durch den vorherigen Konsum von Alkohol oder anderen psychotropen Substanzen.

Die Auslöser verändern sich im Laufe der Zeit während des aktiven Konsums und insbesondere während der Behandlung. Die Wirkung verändert sich ebenfalls im Laufe der Zeit während des aktiven Konsums und während der Behandlung.

Die positiven Effekte des Kokains treten bei abhängigem Konsum zunehmend in den Hintergrund. Ziel der Behandlung ist es, die eigenen Hochrisikosituationen bzw.

Rückfälle bei Abstinenzwilligen sind meistens nicht auf mangelnde Abstinenzmotivation zurückzuführen, sondern eher auf Unvorsichtigkeit oder mangelnde Planung.

Resultate aus der Hirnforschung zeigen zudem, dass Substanzverlangen nach Kokain bei ehemals Abhängigen auch nach Jahren von Abstinenz durch entsprechende Schlüsselreize ausgelöst werden können, d.

Dadurch ist das Abhängigkeitspotenzial um einiges höher als bei den anderen Konsumformen. Die Gefahren, die der intravenöse Konsum mit sich bringt, wie Infektionskrankheiten oder Überdosierung, werden nicht mehr wahrgenommen.

Der intravenöse Kokainkonsum ist häufig begleitet von körperlicher und sozialer Verwahrlosung. Die vorhandenen Suchthilfesysteme im europäischen Raum waren und sind teilweise nur unzureichend auf diese Entwicklung und auf diese Situation eingestellt.

Die meisten ambulanten und stationären Angebote sind auf die Behandlung von Opioidabhängigen angepasst. Rein kokainabhängige Menschen bilden im Vergleich zu Opioidabhängigen eine Zielgruppe mit anderen Bedürfnissen.

Sie sind in der Regel in deutlich anderen sozioökonomischen Situationen sozial integriert und finanziell gesicherter als Opioidabhängige.

Die Behandlung muss stationär geschehen. Grund dafür ist, dass das Risiko sonst zu hoch ist, dass die Betroffen rückfällig werden. Zudem wird meist ein Gespräch mit den Betroffenen geführt, damit sich die Ärzte ein Bild des Patienten machen können.

Nach dem Entzug ist eine weitere Medizinische Behandlung zwingend notwendig, um einen Rückfall zu vermeiden. Dazu können auch Medikamente verwendet werden.

Das statistische Risiko für Kokainkonsumenten, an einer Überdosis Kokain zu sterben, beträgt ein Zwanzigstel gegenüber Heroinkonsumenten, an einer Überdosis Heroin zu sterben.

In Deutschland wurden im Jahr insgesamt 27 Todesfälle gezählt, die direkt mit dem alleinigen Konsum von Kokain in Verbindung standen. In 90 weiteren Todesfällen war Kokain neben anderen Drogen auch involviert.

Von besonderer Bedeutung ist hier einerseits die Mischintoxikation mit Heroin und Kokain und andererseits die von Lidocain respektive Tetracain und Kokain.

Besonders die Verunreinigung von Kokain mit Lidocain stellt ein lebensbedrohliches Problem dar, wie eine Studie aus dem Jahr dreier rechtsmedizinischer Institute in Berlin zur toxikologischen Bewertung der Lokalanästhetika Lidocain und Tetracain bei Drogentodesfällen feststellt.

Hierdurch erhöht sich die Gewinnspanne der am Handel beteiligten Akteure. Sowohl das Landeskriminalamt Berlin als auch das Bundesministerium für Gesundheit warnen daher die Apotheker eindringlich vor einer unkritischen Abgabe von Lidocain.

Einer der Hauptgründe für den Lidocainverschnitt liegt in der lokalanästhetischen Wirkung dieses Stoffes, durch den beispielsweise beim Zungentest Kokain leicht vorgetäuscht werden kann.

Besonders problematisch ist Lidocain- oder Tetracainverschnitt, wenn Kokain weder geschnupft noch geraucht, sondern intravenös injiziert wird.

Letztendlich führte die Lähmung des zentralen Nervensystems oder die Blockade des Erregungsbildungssystems des Herzens zum Tode.

Siehe auch Abschnitt Gefahren durch Streckmittel. Personen mit unentdeckten, an sich harmlosen Herzfehlern können bereits nach einmaligem Kokainkonsum sterben.

Beim gemeinsamen Gebrauch von Schnupfröhrchen kann es bei der nasalen Applikation von Kokain zur Übertragung von Krankheitserregern kommen.

Dies gilt insbesondere für Dauerkonsumenten, da diese häufiger Verletzungen an den Nasenschleimhäuten haben als Gelegenheitskonsumenten.

Zur Kokaingewinnung unter Laborbedingungen werden die Blätter des Cocastrauchs Playtika Games und eingeweicht. Von besonderer Bedeutung ist hier einerseits die Mischintoxikation mit Heroin und Kokain und andererseits die von Lidocain respektive Tetracain und Kokain. Der Europäische Drogenbericht bezieht sich hierzu auf eine Teilauswertung des Global Drug Surveyeine nicht-repräsentative Online-Befragung, wonach unter Eingeschränktes Lernvermögen bei Kokainabhängigkeit: Die Kokainabhängigkeit gilt als besonders hartnäckig in der Behandlung. Die Leber wird durch Kokain Hin Und Her Schicken. Die Auslöser verändern sich Wiki Kokain Laufe der Zeit während des aktiven Konsums und insbesondere während der Behandlung. Nach dem Kokainrausch kann eine Depression auftreten. Kokain PartnerbГ¶rsen Vergleich der Methylester des linksdrehenden Benzoylecgonins. Cocain Crack.

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